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KMID : 0858520070110020103
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Journal of the Korean Society of Magnetic Resonance in Medicine
2007 Volume.11 No. 2 p.103 ~ p.109
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Assessment of Non-permeability of Gd-DTPA for Dynamic Susceptibility Contrast in Human Brain: A Preliminary Study Using Non-linear Curve Fitting
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Yoon Seong-Ik
Jahng Geon-Ho
Khang Hyun-Soo
Kim Young-Joo
Choe Bo-Young
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Abstract
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To develop an advanced non-linear curve fitting (NLCF) algorithm for performing dynamic susceptibility contrast study of the brain. The first pass effects give rise to spuriously high estimates of for the voxels that represent the large vascular components. An explicit threshold value was used to reject voxels. The blood perfusion and volume estimation were accurately evaluated in the -weighted dynamic contrast enhanced (DCE)-MR images. From each of the recalculated parameters, a perfusion weighted image was outlined by using the modified non-linear curve fitting algorithm. The present study demonstrated an improvement of an estimation of the kinetic parameters from the DCE -weighted magnetic resonance imaging data with using contrast agents.
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KEYWORD
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Non-linear curve fitting (NLCF), Dynamic contrast-enhanced (DCE), Kinetic parameters
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